Abstract

Retrospective Study

Can infants develop meningitis in the absence of bacteremia in the first ninety days of life? A retrospective chart review

Krizam G*, Almulla A, Lootah A, Alkatib T and Altatari H

Published: 04 July, 2022 | Volume 5 - Issue 1 | Pages: 022-025

The overall incidence of meningitis in infants 0-90 days is low; however, it remains a serious cause of morbidity and mortality among affected patients. It is standard of care to perform lumbar punctures as part of the work-up of fever in the first four weeks of life and sick-looking babies up to the age of 90 days. This particular procedure is often refused by parents, and physicians are left to predict the possibility of meningitis based on blood culture results.
The aim of this study is to determine whether it would be safe to rule out meningitis based on a negative blood culture in this age group.

Read Full Article HTML DOI: 10.29328/journal.japch.1001047 Cite this Article Read Full Article PDF

References

  1. Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, Harrison LH, Farley MM, Reingold A, Bennett NM, Craig AS, Schaffner W, Thomas A, Lewis MM, Scallan E, Schuchat A; Emerging Infections Programs Network. Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011 May 26;364(21):2016-25. doi: 10.1056/NEJMoa1005384. PMID: 21612470.
  2. Harvey D, Holt DE, Bedford H. Bacterial meningitis in the newborn: a prospective study of mortality and morbidity. Semin Perinatol. 1999 Jun;23(3):218-25. doi: 10.1016/s0146-0005(99)80066-4. PMID: 10405191.
  3. Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100. doi: 10.1542/peds.2005-1132. PMID: 16585303.
  4. Wiswell TE, Baumgart S, Gannon CM, Spitzer AR. No lumbar puncture in the evaluation for early neonatal sepsis: will meningitis be missed? Pediatrics. 1995 Jun;95(6):803-6. PMID: 7761203.
  5. Ku LC, Boggess KA, Cohen-Wolkowiez M. Bacterial meningitis in infants. Clin Perinatol. 2015 Mar;42(1):29-45, vii-viii. doi: 10.1016/j.clp.2014.10.004. Epub 2014 Dec 6. PMID: 25677995; PMCID: PMC4332563.
  6. Griffiths MJ, McGill F, Solomon T. Management of acute meningitis. Clin Med (Lond). 2018 Mar;18(2):164-169. doi: 10.7861/clinmedicine.18-2-164. PMID: 29626023; PMCID: PMC6303447.
  7. Khater WS, Elabd SH. Identification of Common Bacterial Pathogens Causing Meningitis in Culture-Negative Cerebrospinal Fluid Samples Using Real-Time Polymerase Chain Reaction. Int J Microbiol. 2016;2016:4197187. doi: 10.1155/2016/4197187. Epub 2016 Aug 1. PMID: 27563310; PMCID: PMC4983665. 

Figures:

Figure 1

Figure 1

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?